Aspirin Exposure During Pregnancy
Links to Learning Disabilities, ADD and Behavior Disorders
The following is one chapter from a 1997 Graduate Student Research Project
conducted at the
Author: Richard W. Pressinger (M.Ed.)
Lower I.Q. and Increased A.D.D. Symptoms
in Children Linked to Aspirin Use During Pregnancy
SOURCE: Teratology 35:211-219 (1987)
Children born to mothers who took aspirin during pregnancy were found to have lower intelligence scores and increases in attention deficit problems according to a study of 421 predominantly middle income families.
The study, conducted by the Department of Psychiatry and Behavioral Science at the University of Washington, found that pregnant women using aspirin "several times per week" had children whose IQ scores were 10.1 points lower for girls, and interestingly, only 1.3 points lower for boys. The researchers took into account potential confounding factors such as alcohol, smoking, caffeine use and educational background of parents. The testing was done at age 4 using the Weschler Preschool & Primary Scale of Intelligence (WPPSI).
Attention deficits were diagnosed using a standard "vigilance" testing procedure in which the child watched a large display of a Victorian house and was instructed to press a button whenever the silhouette of a cat appeared in a window. The aspirin-exposed children were found to make significantly more "errors of omission," which means the child forgot to press the button when the cat actually did appear in the window.
According to the researchers,
The results of this study are disturbing in that a very large percentage of women (46%) take aspirin during pregnancy. Also of interest, it was found that 41% of the women took acetaminophen (Tylenol) during pregnancy, however, acetaminophen was not found to cause any of the IQ or attention problems found with aspirin. These authors also listed three other studies which found exposure to aspirin during pregnancy inhibited learning, increased activity and caused developmental delays in test animals exposed to aspirin during pregnancy.
There were no changes observed in the growth measurements of weight, length and head circumference (34.5 cm) in the aspirin exposed children when compared to non-aspirin exposed children.
In conclusion, the researchers state,
Dr. Ann P. Streissguth,
Robert P. Treder, Helen M Barr, Thomas H. Shepard, W. Bleyer
Aspirin Retards Growth of Developing Brain
SOURCE: Neurotoxicology and Teratology, 11:135-143, 1989
It has be well documented that using alcohol during pregnancy can interfere with neurological growth in the developing fetus. However, taking aspirin while also drinking appears to greatly increase the amount of damage to the developing brain states a report from the Alcohol and Brain Research Laboratory at the University of Iowa.
Evaluation of the neurotoxicity of these drugs was conducted by exposing 15 groups of pregnant rats to varying dosages of alcohol, aspirin and alcohol plus aspirin. Results showed that the mean total brain weight of the group treated with alcohol alone (no aspirin) was reduced 19.8%, relative to non-alcohol controls. Reduction in brain weight to the aspirin only group was not apparent in the total brain weight but was significant for the cerebellar weight at the highest aspirin dose of 50/mg/kg/day. (This highest aspirin dose would be equivalent to an average woman consuming between 9 or 10 aspirin tablets per day, although scientists stated the comparative dose would actually be smaller because rats metabolize aspirin faster than humans.
The highest dose of aspirin (50 mg/kg/day) caused a mean total brain weight 12.1% lower than the group treated with alcohol alone and 29.5% lower than the non-alcohol controls.
The researchers stated,
Dr. James R. West Ph.D., Daniel J. Bonthius